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It's a polarizing tobacco smokers tend to love it or strongly dislike it but it's a fascinating one to know about
While the nicotine inside the device may be extracted from the tobacco plant (or synthetically created), the vapor you inhale is completely free of tobacco plant matter, tar, carbon monoxide, and the thousands of toxic chemicals produced by burning actual tobacco.
As means of defense, some host plants reduce their root exudate production or produce inhibitors
However, M1 macrophages did not associate with decreased lung function
