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Among these, tobacco-specific nitrosamines (such as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N -nitrosonornicotine (NNN)), polycyclic aromatic hydrocarbons (such as benzo[ a ]pyrene) and aromatic amines (such as 4-aminobiphenyl) seem to have an important role as causes of cancer

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Lammel noted that drugs that block the alpha-7 nicotinic acetylcholine receptor might not work as a treatment for tobacco or nicotine addiction because they would block many necessary functions of the receptor