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Inhibiting Cholesterol Efflux in Airway Epithelial Cells Exacerbates Cigarette Smoke Extract-Induced Inflammation and Apoptosis To further verify the role of cholesterol efflux in cigarette smoke-induced airway inflammation, we silenced the expression of cholesterol efflux-related molecule ABCA1 in HBE cells using ABCA1-siRNA (Figure 5A) and detected changes in CSE-induced secretion of inflammatory factors IL6 and IL8 in airway epithelial cells using qPCR, Western blot, and ELISA