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Cigarette smuggling According to some sources, tobacco smuggling in Italy may have been very high in 1950, as high as 50% of legal sales, and then declined over the next couple of decades to 10-20 per cent of sales.[vi] One source claims that by 1985 contraband accounted for a mere 1 per cent of sales.[vii] That figure seems very low, but if we take the extremes and imagine that smuggling declined from 50% of the market in 1949 to 1% in 1985, then contraband would raise the consumption curve suggested in figure 1 and make for a flat (and much higher) level of consumption over the years 1950-85

This underscores the financial incentive to secure supply chains against cross-border tobacco smuggling

Mechanisms and effects of immunomodulation by cigarette smoke

It can happen during withdrawal as your body adjusts