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8 found that reduced dorsal anterior cingulate cortex (dACC)-striatum FC in 3.5 hours nicotine-deprived smokers correlated with higher nicotine dependence level, while short-term nicotine administration improved the cingulate-neocortical FC

Tieman et al., 2001, and references therein)

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Scientifically, there are those who are pre-disposed to struggle with introducing chemicals to their body