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[26] [27] Some electronic cigarettes contain synthetic nicotine analogues (for example, 6-methyl nicotine, sometimes marketed under the trade name "Metatine") [28] and makers are trying develop nicotine substitutes

The strengths of this study are as follows: (1) it was the first large randomized controlled trial to evaluate the efficacy of a novel smartphone system for smoking cessation integrated with a mobile exhaled CO checker to supplement standard treatment with face-to-face behavioral support and pharmacotherapy