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[141] A 2015 Public Health England report stated that "Smokers who have tried other methods of quitting without success could be encouraged to try e-cigarettes (EC) to stop smoking and stop smoking services should support smokers using EC to quit by offering them behavioural support." [142] However, since little is known about long term effects, other regulated options such as nicotine replacement therapy, varenicline or bupropion should be discussed primarily

The three regions (Europe A and C and Americas D) were excluded, as these were not among those regions included in the INTERHEART study (Additional file 1: Appendix 4)

In Tano, it was said to mean either a roll of tobacco leaves (according to Bartolom de las Casas, 1552), or to tabago , a kind of L-shaped pipe used for sniffing tobacco smoke (according to Oviedo, with the leaves themselves being referred to as cohiba )