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Preclinical models have employed germ-free mice that received fecal transplantation from human alcohol-dependent subjects with severe alcoholic hepatitis (sAH) or no alcoholic hepatitis (nAH) to study how the gut microbiota play a role in the modulation of intestinal permeability and the development of alcohol-induced liver disease (Llopis et al

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For example, smoking cannabis or nicotine can cause degradation to the oral epithelium, the acidic nature of cocaine can be detrimental to jaw integrity, and alcoholic drinks are acidic and alcohol itself can kill oral microbes

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