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doi: 10.1016/j.jprot.2019.103582 Summary Keywords plant virus, tobacco mosaic virus, PEGylation, cell uptake, immune evasion, protein corona Citation Caballero RM, Gonzlez-Gamboa I, Craig SL and Steinmetz NF (2023) Linear and multivalent PEGylation of the tobacco mosaic virus and the effects on its biological properties

The other reason is that the smoke itself contains toxins, called particulate matter