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In vitro studies have shown that Ang II stimulates superoxide anion production in mesangial cells (Jaimes et al., 1998), whereas OxS was shown to be a direct stimulator of AT1R expression in an animal study ( 3.3 OxS and insulin Increased ROS production and OxS caused insulin resistance in vitro and in animal studies (Fazakerley et al., 2018)

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The 3-week half-life of AGEs 75,76,77 may explain that despite the diminished low-grade systemic inflammation AGEs remained elevated