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10 More than half of those who use illicit opioids report experiencing symptoms of a mental illness at some point in their lives, most commonly depressive and anxiety disorders

It is thought that this is due to an increase in acetylcholine and norepinephrine

Severe vitamin B12 deficiency can also cause neurological symptoms, including shaking and numbness, as the body struggles to maintain healthy nerve function

[DOI] [PubMed] [Google Scholar] 53.Zhao L., Shi W., Hu F., Song X., Cheng Z., Zhou J
