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Nicotine is known to rapidly metabolize into cotinine and OH-Cotinine, indirectly contributing to more heightened ROS accumulation 53,54
Among these, tobacco-specific nitrosamines (TSNAs) pose the most significant cancer risk

Thats the finding of new research published in open-access journal Frontiers in Physiology , which also found that mixing e-cigarette flavors has a much worse effect than exposure to just one
