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Thus, real-time smoke formation studies have been reported using systems such as Fourier-transform infrared spectroscopy [16], quantum-cascade infrared laser spectroscopy [1720], dual infrared tuneable diode-laser systems [2124], gas chromatographymass spectrometry with a special puff-resolved trapping mechanism [2528], resonance-enhanced multiphoton ionisationtime of flight mass spectrometry (REMPI-TOFMS) and single-photon ionisationtime of flight mass spectrometry (SPI-TOFMS) [2936]

26 A recent report have suggested that emission of formaldehyde in e-cigarette aerosols is higher than a direct measurement of formaldehyde because a portion of formaldehyde is sequestered in the form of a hemiacetal, which prompted more health concerns over using e-cigarettes