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Treated disease may appear clinically normal, so it is important to have a clear histopathological record of the diagnosis before treatment commences, to help prevent future clinicians from discontinuing treatment because clinical examination findings are now normal

For cohort studies, the age range associated with the RR estimate was calculated as a mean age at baseline plus the mean/median years of follow-up (if only the maximum years of follow-up were reported, we would halve this value and add it to the mean age at baseline)

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