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The hepatotoxicity of PZA is dose-dependent, especially at doses above 40 mg/kg, and correlates with its hepatic metabolism, suggesting a direct toxic effect rather than a hypersensitive or immune-mediated mechanism

One practical consideration: nicotine replacement therapy (patches, gum, lozenges) can produce positive cotinine results even after cigarette cessation meaning a former smoker using NRT to quit may still test positive for cotinine and be classified as a tobacco user at carriers that treat any positive cotinine as smoker-equivalent

Plants produce an average of 20 leaves per plant with a nicotine content of 1%