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in humans, uric acid is the most abundant aqueous antioxidant, accounting for up to 60% of serum free radical scavenging capacity, and it is an important intracellular free radical scavenger during metabolic stress, including smoking [5, 6]

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Historically, wits have referred to it as "the king of diseases and the disease of kings" [5] [113] or as "rich man's disease" [15] for its relationship to a rich diet and obesity

The shank and stem also angle downward, working in tandem with the panels of the heel to achieve a subtle sense of curvature despite the crisp, straight lines that frame the form