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It can cause cancer and a number of noncancerous oral conditions and can lead to nicotine addiction and dependence (5)

Materials Four inserts were identical to those used in Canada, except that information at the base of the insert (all mentioned Health Canada and two stated that Nicotine is the drug in tobacco that causes addiction) was replaced with a self-efficacy (You can quit) or response efficacy message (You will benefit from quitting), given that efficacy messages on inserts have been found to complement the warnings on packs, 28 see Figure 1

and AURI in Canada (Supplementary Table 5)

These harmful effects on kidney function/structure are dependent on the dose and duration of cigarette smoking