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What we found, says Hillel Alpert, is that they added ingredients particularly pyrazines that appear to have contributed to the smooth flavor, reducing the harshness of certain cigarettes. Pyrazines are also being added to e-cigarette fluids, his team wrote online June 10 in Tobacco Control

While the pharmacokinetic results are interesting, this hypothesis requires thorough evaluation in clinical trials, which ideally compare NPs to conventional oral forms of NRT(Grandolfo et al., 2024)

Some trial participants described adverse effects, including suicidal thoughts and attempts, which they attributed to the trial, but which they say Lykos hid in their clinical trial results including phase 2 trial results originally published in the journal Psychopharmacology