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In eight studies in which the effects of smoking cessation on endothelial function were assessed by biomarkers[19, 20, 23, 24, 30, 31, 92, 93], five studies showed that smoking cessation increased or improved biomarkers for endothelial function including circulating levels of nitrate/nitrite, NO, vvWF, ICAM-1, EPCs and EMPs and activity of eNOS [19, 23, 24, 30, 31]

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These data and analyses will provide more robust evidence about familial contexts to help explore these relationships, to inform subsequent research, and also to inform substance use cessation interventions both to help prevent initiation and encourage cessation of substance use in teenagers