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3.5 PD-1, PDL-1, and PDL-2 The programmed cell death protein 1 (PD-1) receptor and its ligands, programmed death-ligand 1 (PD-L1) and PD-L2, are essential components of the immune checkpoint pathway that regulates immune homeostasis

They analyzed some of these toxic components, ran a mutagenicity test on smoke condensates, and compared the results to the corresponding values of a standard cigarette with the same tar content, which when measured was higher than that stated on the package