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Nicotine can lead to changes in the gut bacteria which have been associated with IBS symptoms

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Acknowledgements This study was supported in part by NIDA grants: 1R56DA036556, R01DA029845, R01DA030394, R01HL102119, and R21DA032022, Natural Science Foundation of Zhejiang Province Grant LZ15H180001, the program for professor of special appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning, and the Hangzhou Qianjiang Endowed Professor Program and the Youth 1000 Talent Program of China

Respiratory Health: Studies have found that inhaling vapor can cause airway inflammation and reduced lung function over time