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In a smoky room of the Warner Brothers studio lot, Frank Sinatra, Marilyn Monroe, Ella Fitzgerald, Sammy Davis Jr., and Dean Martin slip away from the glittering set of Oceans 11

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The figure depicts the major established pathways of cancer causation by cigarette smoking: (1) the exposure to carcinogens (cancer-causing substances), (2) the formation of covalent bonds between the carcinogens and DNA (DNA adduct formation), and (3) the resulting accumulation of permanent somatic mutations in critical genes (genes appear in italics)

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