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Since the average life expectancy of individuals with schizophrenia is between 61 and 71 years, with cardiovascular disease accounting for as much as 50% of excess mortality in schizophrenia, the issue of tobacco smoking is therefore very relevant in terms of prognostic implications [8]
Smoking increases the mutation burden across multiple cancer types, with specific signatures linked to direct exposure to tobacco carcinogens like benzo[a]pyrene
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