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For FDA to approve a cigarette plan for cigarette packaging, the plan must provide that all of the required warnings are randomly displayed during each 12-month period on each brand of the product, displayed on each brand of the product in as equal a number of times as is possible during each 12-month period, are randomly distributed in all areas of the United States in which the product is marketed, and must ensure that all of the required warnings will be displayed by the manufacturer, distributor, or retailer at the same time

Ethics declarations Ethics approval and consent to participate this study was approved (IR.UMSHA.REC.1402.249) in on Ethics Board of the Hamadan university of Medical Science

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Cigarettes held the highest input level followed by smokeless tobacco and then nicotine gum and the younger group of subject came out to have the highest rise in nicotine levels