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Description
it was John Rolfe who in 1612 obtained Spanish seeds, or Nicotiana tabacum , from the Orinoco River valleyseeds that, when planted in the relatively rich bottomland of the James River, produced a milder, yet still dark leaf that soon became the European standard

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[DOI] [Google Scholar] Nachnani R
Initially, the PAFR levels in the nasal tract of all 17 volunteers were measured
