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Most studies included found no significant association

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Code year: FY2026 (Oct 1 2025 Sep 30 2026) Audience: Certified Coders, Auditors and Clinical Documentation Specialists Access: CCO Members Last updated: April 2026 Definition Drug dependence (substance use disorder) is a chronic, relapsing brain disease characterized by compulsive drug seeking and use despite harmful consequences, driven by neurobiological changes in reward, stress, and inhibitory control circuits

This article documents the smoking epidemics rise and fall in the 20 th century in a gender perspective