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[1] The IARC monographs conclude that mice with prolonged exposure to simulated second-hand smoke, that is six hours a day, five days a week, for five months with a subsequent four-month interval before dissection, will have significantly higher inicidence and multiplicity of lung tumors than with control groups

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Check out the weighted harm scale of the different nicotine products: Tobacco-free oral nicotine, in terms of the relative risk hierarchy, is estimated to be marginally more harmful than the least harmful category, NRT products