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In the current season of the popular Netflix political series House of Cards, the main character, Frank Underwood, is caught by his wife smoking a cigarette

Within 3 hours, the person may experience anxiety, sadness, and difficulty concentrating

It is now understood that different receptors, including transient receptor potential vanilloid 1 (TRPV1), transient receptor potential ankyrin 1 (TRPA1), and purinergic P2X channels, are stimulated by subtypes of nasal, bronchial, and, pulmonary C-nerve fiber (184188)

FDA has recently reclassified bupropion as a pregnancy category C drug, meaning that either (1) animal studies have demonstrated that the drug exerts animal-teratogenic or embryocidal effects, but there are no controlled studies in women, or (2) no studies are available in either animals or women