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For the past eight years Ive more or less rigorously controlled my smoking, interpolating scenes from my smoking life with others from my ruminant one

Bortus first materializes one cigarette, which Klyden picks up and examines before eating it

Later work demonstrated that the combined absence of the p53 target genes encoding the pro-apoptotic BH3-only proteins PUMA and NOXA (and to a lesser extent loss of PUMA alone) rendered lymphoid cells as resistant to DNA damage-inducing agents as loss of p53 itself [8, 9, 22]
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