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3 , 4 The risk of death increases in proportion to the extent of exposure to cigarette smoke
Development of oxidative stress (OxS), hyperinsulinemia and insulin resistance, subclinical inflammation, and dysregulation of the sympathetic nervous system (SNS), renin-angiotensin aldosterone system (RAAS), and immune system have been identified as major alterations in this context
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He added its chronic use was likely to be damaging to the airways
