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I think this matters for two reasons
Posttranslational modification of histones involves covalent modification of specific sites and residues that form specific three-dimensional arrangements of nucleosomes that control the accessibility to transcriptional factors to genes to induce gene expression

Gatti, A., Li, H

In 2012, the Winter Garden, a theater in Toronto, got a call from the public health department after Chappelle smoked like a chimney throughout his three-show stint
