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[DOI] [Google Scholar] 17.WHO | WHO Global Report on Trends in Tobacco Smoking 20002025First Edition

This triggers chemical reactions that activate brain receptors, releasing dopamine and other neurotransmitters that induce pleasurable sensations
These results suggest that the injury caused in the epithelium barrier can lead to the exposure of lumen antigens, which can be recognized by immune cells whose recruitment is increased, inducing the development of CD (Figure 1)

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