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While e-cigarettes are believed to expose users to fewer toxicants than tobacco cigarettes, there remains concerns regarding their long-term safety and potential health risks, including instances of respiratory and cardiovascular issues, as well as the possibility of e-cigarettes serving as a gateway to smoking tobacco - though evidence suggests there is little-to-no gateway effect

It is now known that HBV can spread by sexual contact, the transfer of blood or serum through shared needles in drug abusers, accidental needle sticks with needles contaminated with infected blood, blood transfusions, hemodialysis, and by infected mothers to their newborns