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In vivo PK profile data of drugs, such as the vasodilators for treating IUGR (Sharp and Alfirevic, 2015), are very rare
Additionally, the reduction of side effects associated with smoking such as chronic cough, shortness of breath, and alterations in taste and smell can contribute to an overall sense of well-being
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Large clusters of puffs in relatively quick succession result in a near-bolus dose of nicotine, rapid rise in blood nicotine levels, and likely greater nicotine-related effects (positive reinforcement)
