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In male mice exposed to 100 ppb of sodium arsenite in utero and after birth, along with a western-style diet (containing 40.1% fat, 15.5% protein and 44.4% carbohydrates), there were an increase in body weight, liver weight, and serum cholesterol levels ( Although the possible mechanisms of arsenic as an obesogenic agent are not entirely understood, it could also influence adipose tissue dysfunction

We cant do either of those things, obviously. So they looked to an advanced statistical approach causal inference in which they compared users and non-users of e-cigarettes who started the study with similar known risk factors for vaping based on a variety of factors, including alcohol use, marijuana use, impulsivity and their parents education levels and tobacco history