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These detrimental effects are mediated by complex mechanisms, including direct hepatotoxicity, oxidative stress, immune dysregulation, oncogenic signaling, and systemic metabolic disturbances

Per executive order from then-Governor John Rowland, Connecticut became involved in the project as a participating state, meaning Connecticut is involved in the project but has not implemented the required statutory changes

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14 Opening the door to regulating ENDS as OTC drugs, FDA leadership wrote: When it comes to the discussion around transitioning current smokers to safer alternatives for the delivery of nicotine, a lot of public debate, to date, has been placed on the potential for modified risk tobacco products like [ENDS] and e-cigarettes