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Ji H-L, et al

We answer all of it and more in this shame-free guide to BV
Nicotine has toxic effects on the endothelium, and thus nicotine may play a key role in impaired nitric oxide synthase-dependent vasoreactivity observed in tobacco users

No, carbon monoxide (CO) is not toxic to touch because it is a gas at room temperature and does not have any direct effects on the skin