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[66] Heating these flavorings releases toxic chemicals [67] and carcinogens such as carbon monoxide (CO), polycyclic aromatic hydrocarbons (PAHs), furans, phenols, aldehydes (such as acrolein), and acids, in addition to nitrogenous carcinogens, alcohols, and heavy metals, all of which are dangerous to human health

These higher doses tended to induce a non-significant increase in the brain reward thresholds of the control rats and were less effective in attenuating the elevations in brain reward thresholds associated with nicotine withdrawal than lower doses

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Increasing social acceptability of alcohol and smoking, and increasing socialization also has some role