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A significant limitation of the study was the relatively small number of people who were using e-cigarettes at the beginning of the trial, making it difficult to be confident that the results would be replicated in a larger e-cigarette user sample

There is some question, however, to the safety of adding some flavorings, because while they may be FDA safe, that is for ingestion, not necessarily combustion

However, people who have been vaping may have been exposed to higher nicotine doses than traditional cigarette smokers, and so high doses of nicotine replacement may be needed

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