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By 1700, after nearly a century of European immigration to the New World, the supply of willing white immigrants was inadequate to meet demand - witness the problems Governor Spotswood faced trying to get iron workers to his lands at Germanna

There also has been an increased focus on the negative health effects of occupational exposures for firefighters

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For other cancer sites, the RRs for current smokers ranged from 1.10 to 6.70 for cancer incidence and from 1.10 to 3.30 for cancer mortality, except for a few cases where the RR was estimated to be less than one with insignificant p-values (Table 1)