4 days without a cigarette 24 Hours After Quitting Smoking: What Happens to Your Body? Nicotine Withdrawal: What to Expect
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As such, e-cigarette manufacturers now have less than a year to submit market approval applications if they want to keep selling ENDS

The mechanism relates to nicotine binding with acetylcholine receptors in the sweat gland and duct, to change their structure and induce inflammation
(1987) Burning Bright: The Autobiography of Edward Wharton-Tigar , London: Metal Bulletin Books, p.254 "World Record $3.12 Million for T206 Honus Wagner Baseball Card"

Factors influencing electronic cigarette use Electronic cigarette harm perception A multitude of factors influence the likelihood to initiate electronic cigarette use (18)