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Our cigarette brands In recent years, our Groups share of the cigarette market has grown consistently, largely driven by our five global brands Dunhill, Kent, Lucky Strike, Pall Mall and Rothmans

Abbreviations BMI: Body Mass Index CDK: Cyclin-dependent kinases CI: Combination index COX-2: Cyclooxygenase 2 DMSO: Dimethyl sulfoxide DNA: Deoxyribonucleic acid DSB: Double strand break DYRK1A: Dual-specificity tyrosine-phosphorylated and regulated kinase 1A EGFR: Epidermal growth factor receptor EMT: Epithelial-to-mesenchymal transition FAP: Familial adenomatous polyposis GSK-3: Glycogen synthase kinase 3 GSLC: Glioblastoma stem-like cells HDAC: Histone deacetylase HMH: Harmine hydrochloride HPLC: High-performance liquid chromatography HPV: Human papillomavirus HR: Homologous recombination IL-2: Interleukin-2 MAPK: Mitogen-activated protein kinases MMP: Matrix metalloproteinases mTORC1: Mammalian target of rapamycin complex 1 NB: Neuroblastoma NF-B: Nuclear Factor kappa B NHEJ: Nonhomologous end joining NO: Nitric oxide NSCLC: Non-small cell lung cancer PARP: Poly (ADP-ribose) polymerase PI3K: Phosphatidylinositol-3-kinase PTEN: Phosphatase and tensin homolog Raf: Rapidly accelerated fibrosarcoma (Raf) kinase Ras: Rat sarcoma (Ras) protein RK: Extracellular-signal-regulated kinases SAR: Structure-activity relationship SRB: Sulforhodamine B TAZ: Transcriptional coactivator with PDZ-binding motif TCF/LEF: T-cell factor/lymphoid enhancer factor THH: Tetrahydroharmine TLC: Thin layer chromatography TRAP: Telomerase repeated amplification procedure

In 2019, 18.4 per cent of people aged 15 years and over in the EU were daily smokers according to EUs official statistical office, Eurostat

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