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Abstract Nicotine is the primary pharmacologic component of tobacco, and its highly addictive nature is responsible for its widespread use and significant withdrawal effects that result in challenges to smoking cessation therapeutics

The relationship between the two states has been tense since the Dominicans fought for independence from Haiti in 1844

For example, in Canada many chain convenience stores sell IQOS HEETS, but not the device itself, and store clerks inform customers to contact an IQOS representative to arrange for the device purchase.9 In Korea,10 PMI markets its IQOS holder, charger and related accessories in packages that do not contain the HEETS labelled only as IQOS without any reference to tobacco or health warnings required on tobacco product packaging

To keep others safe, it is recommended to vape outdoors and be careful about using vaping products around others