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c Propensity score matching (PSM) was performed to balance 12 confounders, including age, sex at birth, race/ethnicity, youth pubertal stage, ever use of tobacco, past 6-month marijuana use, parental education level, parental income, parent monitoring, prenatal tobacco exposure, history of substance use, school environment factors, and child mental health assessed according to DSM-5 criteria

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Yet, recent e-cigarette research contradicts this: protonated salts (e.g., nicotine benzoate, lactate, levulinate from acid addition) yield higher Cmax and faster onset than equivalent free-base [165]