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Delirium is associated with a range of adverse outcomes, including prolonged hospital stays, increased mortality, long-term cognitive impairment and higher healthcare costs [25,26,27]

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Collectively, our results suggest that the involvement of TRPM8 is greater in the responses to M-CS than in the responses to Non-M-CS possibly because of the additional action of menthol in M-CS on TRPM8

Thus, few studies suggest that smokers have a higher SHBG level compared to non-smokers 25,27