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Supplemental material Cooling flavouring chemical analysis Neat standards of the 16 cooling flavouring chemicals, including l-menthol and synthetic coolants WS-3 and WS-23, and internal standards assessed in the study were purchased from multiple vendors (online supplemental table 1)

ZYNs are combustion-free, so they drastically reduce exposure to chemical toxicants

Smoking can cause plaque formation in the arteries

Although the average baseline risk for COPD is 4%, this rate can vary by 2-6% in some regions
