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Since we define chewing tobacco exposure as a dichotomous risk factor, i.e., an individual either currently chews tobacco or does not, the risk-outcome score (ROS) is calculated as the signed value of natural log(BPRF) divided by two

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Cigarette smoking and inflammation: cellular and molecular mechanisms

If these trials proceed, they would be the first to evaluate a nicotine cessation therapy in this patient population, which may have quitting needs and challenges distinct from combustible cigarette users