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After listening to 84 witnesses and perusing tens of thousands of exhibits, U.S
In September 2020, the FDA started reviewing premarket tobacco applications and has since issued marketing denial orders for 55,000 flavored ENDS products, on the grounds the applicants dont have sufficient evidence that the benefit to adult smokers outweighs the risk to youth

Pauly et al., 1992

Smoking causes several problems like dry mouth, which leads to tooth decay, gum disease, and bad breath