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Since several in vitro studies have demonstrated how nicotine affects extracellular matrix disintegration, F-actin structure, and actin overexpression, it has long been considered that nicotine may disrupt the function of the cellular skeleton

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The same study found that the following side effects were reported by patch wearers less frequently: diarrhea, dizziness, coldness in limbs, vomiting, and fast or pounding heart beat