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It should be noted, however, that 6% COHb reduced skeletal muscle fatigue resistance 24 and the 3% COHb in our participants may not have had a measurable impact on the oxygen delivery to the skeletal muscle, and hence the fatigue resistance

American Journal of Public Health 95(6):1036-1042

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To put that number in perspective, The National Fire Protection Association (NFPA) claims that air levels of just 400 ppm can cause headaches and nausea in as little as an hour